The information is NOT to be used for diagnosis or treatment of your pet. New comments cannot be posted and votes cannot be cast. Of these, alpha-adrenergics gave the best results but, even then, more than half of the dogs failed to respond to therapy. In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase.4 Similarly, short-term dosing of phenylpropanolamine at 10 the recommended dose for 21 days resulted in hypertension, bradycardia, vomiting, leukocytosis, thrombocytosis, and elevations in ALT. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. 16. That is encouraging. 11. Rec. A treatment for female canine urinary incontinence that contains estriol, a naturally occurring, short-acting estrogen found in female dogs with the convenience of once-a-day dosing. (1996) Urethral sphincter mechanism incompetence in male dogs: a retrospective analysis of 54 cases. Urology. Hanson KR, Ware WA. Generally, therapy with phenylpropanolamine is safe; however, routine blood pressure monitoring should be performed to screen for hypertension, and special consideration should be taken before prescribing phenylpropanolamine to animals with behavioral concerns. Freedom of Information Summary. WebDES Compounded vs. Incurin Tablets Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products The recommended dose of Proin ER is 2 to 4mg/kg PO q24h (to be given with food).10 Proin ER is available in 18-, 38-, 74-, and 145-mg tablets. A urodynamic and clinical evaluation. The information is NOT to be used for diagnosis or treatment of your pet. Holt, P.E. In humans and certain animal species, sympathomimetic drugs are linked with birth defects, but the issue is not confirmed in pets. These have mainly involved pexy of the deferent ducts to the abdominal wall (Weber et al 1997) although the author has used prostatopexy (in castrated males) to the prepubic tendon. Compare Incurin Tablets vs. Proin ER with a detailed product breakdown. The additional benefit is that Incurin is FDA approved and commercially available while DES has to be compounded. Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice The mechanism of action is similar, but this drug needs to be administered three times per day. NADA 141-325. Hamaide AJ, Grand JG, Farnir F, et al. Urol Int. Nol S, Cambier C, Baert K, et al. We never reprimanded her for it of course, since she couldn't help it, but she would often try to lick the spot on her bed to cover up the evidence. Overview Incurin is a veterinary medicine used for the treatment of hormone-dependent urinary incontinence resulting from sphincter mechanism incompetence (SMI) in ovariohysterectomised bitches (i.e. Your comment will be removed, and you may be banned. 21. INCURIN and PROIN are also the only marketed estriol and phenylpropanolamine products that are manufactured to meet FDAs strict standards for quality, purity, and potency. I will make a note of both of those and save them in my bookmarks :-). October 2020. Yes, you can give your dog Proin for control of urinary incontinence. Was cost a factor to you when picking one? After the initial load we only had to give her one pill a week, which is hardly anything. Ten percent of bitches fail to respond at all to colposuspension and the complication rate is low. These effects are reversible after lowering the dose. Can be Incontinence is likely to occur when intra-abdominal pressure increases (e.g., during recumbency) and affected animals tend to have intrapelvic bladder necks, although a short urethra does not appear to be a factor in males (Power et al 1998). 20. Ahlstrm K, Sandahl B, Sjberg B, et al. Here is the link: http://www.i-love-dogs.com/forums/doroin-read.html University of Bristol, Department of Clinical Veterinary ScienceLangford, Bristol, UK. Hamaide AJ, Grand JG, Farnir F, et al. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase. Atalan, G., Holt, P.E. She received her veterinary degree from OSU, where she also completed her residency and masters degree. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. 133, 177-180. Create an account to follow your favorite communities and start taking part in conversations. Since it is not controlling the problem, then I am concerned that Sasha may have some other condition that is causing her symptoms. WebProin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed They had me double he dosages of proin but it did not solve her leaking problem. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. That will teach you to keep your mouth shut." Expand section Collapse section Heartgard for Dogs: How it Works and What it Does? Your thoughts/comments/experience would be greatly appreciated! 2002;43(11):493-496. In the authors experience, dogs affected with USMI that do not respond to phenylpropanolamine may respond to estriol or vice versa, and in some cases combination therapy is warranted. PROIN chewable tablets. 1984;20(4B):10051013.1. Weber, U. T., Arnold, S., Hubler, M. & Kupper, J.R. (1997) Surgical treatment of male dogs with urinary incontinence due to urethral sphincter mechanism incompetence. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. While we provide information resources and canine education, the content here is not a substitute for veterinary guidance. A similar variation in response is also seen with the use of alpha-adrenergic drugs Oestrogens sensitise the urethral smooth muscle to alpha-adrenergic stimulation and so a combination of oestrogen and alpha-adrenergic therapy may be useful and reduce the dose of each individual drug, lessening the chances of side effects. This thread is archived . Aust Vet J. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. Keep in mind that the info in this article is purely educational. To minimize the risk of possible side effects, Proin can be used but with caution in: On the other hand, Proin must not be used at all in: Since, the safe use of Proin in breeding dogs, pregnant and lactating females is not evaluated, it is best not to use the medication in these situations and avoid potential side effects. I think i am leaning towards the DES so far, but i have yet to ask my vet about that one. Holt,P.E .&Thrusfield,M.V. Since Proin increases thirst, make sure your dog has ample fresh water within easy reach while supplementing. Accessed Forsee KM, Davis GJ, Mouat EE, et al. The active ingredient Phenylpropanolamine is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. White, R.A.S. 17. Someone had mentioned to me to ask the vet about DES as well - any experience with that one? WebIncurin Tablets vs. Proin ER Comparison | PetMeds. 59, 673-679. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. Thank you. She started leaking urine when would lay down about 3 years ago. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). -- Ernest Hemmingway, http://www.leospetcare.com/incurin-estriol-is-not-the-same-as-ovaban-des/. Well tolerated in a long-term field study (42-month) involving 324 client-owned ovariohysterectomized female dogs. Proin for Dogs: A Simple Solution for Urinary Incontinence, Yes, you can give your dog Proin for control of urinary incontinence. After urinary incontinence is controlled, the lowest effective daily dose of Incurin should be determined by decreasing the dose in a step-wise manner from 2 mg once daily (2 tablets) to 1 mg once daily (1 tablet), then 0.5 mg once daily (1/2 tablet) depending upon the response of the individual dog. Dogs with a predilection for high blood pressure. Most things i have heard about it are pretty positive so far. Those that do not may be candidates for medical or surgical management (see acquired sphincter mechanism incompetence). Incurin is another FDA-approved Am J Epidemiol. However due to the ease of dosing, high efficacy and safety of PROIN ER, it would be appropriate to prescribe PROIN ER first line for at least 30 days to evaluate whether another option should be explored. Scott L, Leddy M, Bernay F, Davot JL. No medical reasoning behind the decision other than dogs cant be on both.. The congenital condition is often associated with gross prostatic/pelvic urethral deformity and is unlikely to be successfully treated. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266053/, https://www.aaha.org/publications/newstat/articles/2019-04/fda-approves-new-once-a-day-treatment-for-urinary-incontinence-in-dogs/, https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881, https://pubmed.ncbi.nlm.nih.gov/19282207/, https://pubmed.ncbi.nlm.nih.gov/10839324/. I had switched her to a new practice that was closer to Vet. Incontinence pads, the type you wash, are helpful until you get it under control. All dogs should receive an initial dose of 2 mg (two 1-mg tablets) orally once per day for a minimum of 14 days. Gynecol Obstet Invest. Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. It's off the human market. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. Affected spayed bitches may respond well to oestrogen therapy but in some animals the response ceases eventually, despite increasing the dosage of oestrogens, possibly due to desensitisation of oestrogen receptors. Freedom of Information Summary. In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. Proin, PPA for Urinary Incontinence in Spayed Dogs The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. Dogs should not receive more than 2 mg of Incurin per day (2 tablets). Similar results have been obtained with urethropexy (White 2001). Missing Sparks with every breath.Passion 10/16/02-5/25/17, lol! She does not pee in the crate when I'm at work. Currently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, Vtoquinol). I'd also consult with a holistic vet to get the CAUSE of the incontinence. 4. Special stock for AutoShip customers. Can I Give My Dog Aspirin? Incurin contains the active substance estriol. WebProven effective in reducing or eliminating urinary incontinence. 125, 478-480. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Association of sympathomimetic drugs with malformations. Azmira has an Incontinence Formula. Took her in for a lot of tests and the vet came back with older fixed female dogs have this problem some times and prescribed her proin. This only started near the end (and the seizures), before that she never did that in the house. WebCurrently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, Your IP: Is there a big difference between the two in how an old girlie will respond to it? Approximately half of affected bitches become continent following their first oestrus and should thus not be spayed earlier! 1987;8(5):497-505. Based on the relatively low frequency and mildness of the adverse events and their level of association with estriol, no safety concerns associated with longer-term use of the product were observed.1,2, Estriol has been safely used worldwide in dogs for more than 16 years. DES and incurin are given at different frequencys . This movement is more pronounced in bitches with urethral sphincter mechanism incompetence than in normal animals, suggesting a deficiency in supporting mechanisms in the lower urinary tract of affected animals. The dose of Incurin is not dependent upon body weight. U.S. Food and Drug Administration Center for Veterinary Medicine. Special stock for AutoShip customers. There should be a minimum of 7 days between each dose adjustment. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants.7 Phenylpropanolamine should not be given within 2weeks of a patient receiving a monoamine oxidase inhibitor such as amitraz.7 Finally, anesthesia with halothane is associated with an increased risk of arrhythmias and should be avoided.7, In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. Incurin for Dogs. After a month, the vet office called and said they accidentally filled both prescriptions and that she should only be on the incurin. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. It is unlikely, therefore, that anyone form of treatment alone will cure 100% of cases in the long-term. 1988;32(2):273-280. Kim and Bruce- with Rick (Rick Roufus 6/30/16) and missing my sweet greyhound Angels Rainey (LG's Rainey 10/4/2000 - 3/8/2011), Anubis (RJ's Saint Nick 12/25/2001 - 9/12/12) and Zeke (Hey Who Whiz It 4/6/2009 - 7/20/2020) and Larry (PTL Laroach 2/24/2007 - 8/2/2020) -- and Chester (Lab) (8/31/1990 - 5/3/2005), Captain (Schipperke) (10/12/1992 - 6/13/2005) and Remy (GSP) (?/?/1998 - 1/6/2005) at the bridge"Always do sober what you said you'd do drunk.
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